CBD as a fast acting anti-depressant

One of the worst parts about depression, besides the endless days of sorrow, is finding an anti-depressant that actually works. One pill makes you turn into a zombie, the other one makes all of your symptoms worse, and some do nothing at all. It wouldn’t be so bad if we didn’t have to take the pills for a few weeks to find out how they react in our bodies, making the process last for months if none of the prescriptions are the right fit. A new study has revealed that CBD oil might be the new treatment for anti-depression and a solution to this problem.

An exciting new study has shown that CBD may act as a fast-acting antidepressant. In the study, there were rodent models who were administered CBD oil and monitored to research the anti-depressant effects. In just thirty minutes, they found that CBD was expressing anti-depressant like effects that are pretty incredible.

CBD May Elevate Important Chemicals Related To Depression

Cannabidiol was elevating genes and proteins that have shown to be at lower levels in patients with depression. The first being synaptophysin, which is a protein where we aren’t entirely sure what the exact function is. What we do know, is that when animals are lacking in this protein, they can function normally but have shown to have behavioral changes.

PSD-95 was also increased when the scientists gave rodent models CBD, another protein that is at lower levels in people with depression. This protein has shown to play a role in maintaining stable synaptic connections in the brain, which we need for healthy cognitive functions.

The chemical BDNF was elevated in the rodent models, which is like your brain’s fertilizer. It helps with growth in the brain and helps to repair any damage or neuron loss that may have happened. This chemical was elevated in the medial prefrontal cortex and the hippocampus, which is where scientists have discovered may be damaged in people with depression.

These new findings could be a complete game changer when it comes to finding the right anti-depressant for you. The more researchers dive into the effects, the more they are discovering that CBD oil may not only help relieve symptoms but heal the brain making it an actual treatment. No one likes to be bound to a pill for the rest of their life, and CBD oil may be a way to eliminate depression entirely.

CBD For Symptoms Of Depression

While CBD Hemp oil may be helping the brain find its healthy balance, it is also working to improve some of the common symptoms of depression as well. While treating the actual depression is essential to completely get rid of these symptoms, as your brain heals CBD may be able to help you deal with these symptoms making the journey less excruciating.



One of the most common symptoms of depression is anxiety. These go hand in hand because researchers believe that stress could be behind the damage that causes depression.

Cannabidiol may be able to help with anxiety because of its ability to reduce the overactivity in your brain. When anxiety takes hold, it is making your brain send constant fear signals even when there is no threat present. This is because your amygdala and hippocampus aren’t functioning correctly. In studies, CBD has shown to reduce the activity in the amygdala which is where you get the sense of fear. This may be because of the endocannabinoid anandamide.

While most messages in your brain travel from the presynaptic nerve to the postsynaptic nerve, endocannabinoids like anandamide move backward through a process called retrograde signaling.

The endocannabinoids travel from the postsynaptic cell to the presynaptic cell sending a message to either stop sending out so many signals or to send out more. Anandamide binds to the CB1 receptors on the neurons, which help control your neurological system. This includes things like your sleep cycle, appetite, sensitivity to pain, and mood which means it is possible that anandamide is behind the calming effects of CBD.


Pain is also very common among people who have depression. Sometimes, it’s because people who have chronic pain’s quality of life suffers from their condition causing them to become depressed. It also could be because both depression and pain are closely related in brain regions and neurological functions. Studies have shown that depression can cause people to experience aches and pains, and CBD may be able to help.

The endocannabinoid mentioned earlier, anandamide, may be behind the pain-relieving effects of cannabidiol. Through retrograde signaling, anandamide can inhibit the production of pain signaling making you feel less pain.


Fatigue is one of the most common symptoms all across the board when it comes to diseases and disorders. And fatigue is more than just being tired because you may still feel this overwhelming sense of weakness even after a good night’s rest.

Cannabidiol has shown in studies to be a wake-promoting agent, which means it might be able to give you a boost of clean and natural energy. The endocannabinoid anandamide is also a chemical that is released while you exercise, making CBD give you a similar sensation to a runner’s high when you take it which can boost your energy.

Weight Changes

Weight Change

Some people when they are depressed eat their feelings because they crave that dopamine reaction they get when they eat food. Other people can’t eat because everything in the refrigerator looks like cardboard and they would rather sulk on the couch, anyway.

Cannabidiol may be able to help with both of these issues because it acts as a regulator in your endocannabinoid system. If you have become underweight from depression, CBD oil may be able to help boost your appetite through elevating the endocannabinoid anandamide.

Cannabidiol may also be able to help if you are overweight by regulating your appetite, so you aren’t hungry as often as well as helping the weight loss process along. It can help with weight loss by enhancing the fat browning process your body does when you exercise. While doing activity, your body browns fat cells so that they can be burned for energy. If you find that you can’t trim off the excess fat, CBD may be able to help.


If you suffer from insomnia, this condition can make your symptoms worse. A full night’s rest is imperative to your health mentally and physically. Insomnia could come from the anxiety that you feel, and CBD hemp oil might be able to help.

Like mentioned before, cannabidiol acts as a regulator. When taking it regularly as a supplement, it may be able to help regulate your sleep cycle, making it easier for you to fall asleep when it’s time. It also has shown in studies to help promote REM, which can help you feel more rested after sleeping.

Talk To Your Doctor

If you have depression, it is likely you are already on anti-depressants. If you would like to make the switch to CBD, discuss this change with your doctor. If you quit your medication without assistance, it could make your symptoms worse including suicidal thoughts. Your doctor knows how to wean you off your medicine in a way that is beneficial to you, so don’t count them out of this decision. They can also help monitor your progress so you can make sure that CBD is the best treatment option for you.

About The Author

Sarah Potts is a writer at CBD Instead, which is a fun and loving company that is dedicated to sharing the knowledge about medical cannabis with great products so others can experience their own version of relief. To check out more of Sarah’s writing, visit CBDInstead.com!